LOGO
EN

Improvement of mental state and increase of body mass after short-term olanzapine therapy

Affiliacja i adres do korespondencji
Streszczenie

Olanzapine is a 2nd generation antipsychotic drug, whose introduction created wholly new perspectives in the treatment of schizophrenia and other psychoses. These drugs feature a different profile of adverse effects than classic neuroleptics. Olanzapine may cause sedation, metabolic disorders and, as demonstrated by most studies, both short- and long-term, a significant increase of body mass, usually much greater than in the case of other antipsychotic drugs, both classic neuroleptics and 2nd generation antipsychotics. The exact mechanism of this phenomenon has not been fully elucidated yet and may result in part from affinity of olanzapine to serotonin receptor (5HT2A/2C, 5HT3, 5HT6), dopamine receptors (D1-D5), cholinergic, muscarinic (M1-M5), α1-adrenergic and histaminergic H1 receptors. Olanzapine selectively reduces stimulating activity of dopaminergic neurons of the mesolimbic system, while only slightly influencing the nigrostriatal system. Significant increment of body mass may lead to obesity, which is associated with an increased risk of many diseases and higher mortality. Authors present the results of studies concerning differences in improvement of mental state assessed by CGI-I and CGI-S scales in persons with and without significant increase of body mass after short-term (8 weeks) treatment with olanzapine. In both groups a decrease of CGI-S score was obtained, although it was more pronounced in the group of patients with significant body mass increase. Based on these results, it may be concluded that patients, who gained more weight better responded to therapy and obtained greater mental state improvement.

Słowa kluczowe
olanzapine, significant body mass increase, obesity, improvement of mental state