The relationship between psychiatry and dermatology is a multidimensional one and begins at early stages of development. It is generally believed that mental disorders in dermatological patients are secondary to skin symptoms. Nevertheless, in some cases they may be primary conditions or may directly affect the course of skin disorders. It is known that emotional factors considerably influence the majority of dermatological conditions and there are correlations between stressful events and aggravation of skin symptoms. It is important to diagnose and treat concomitant mental disorders in dermatological patients due to the frequency in which they occur and their influence on the quality of patients’ life. A separate and significant psychodermatological problem in the adolescent population is intentional non-suicidal self-injury (NSSI), usually performed to relieve mental tension. An early diagnosis of such a disorder by a dermatologist and a proper psychiatric intervention may effectively prevent an increase in suicidal risk. Patients with skin lesions require holistic approach as well as a thorough, multifaceted analysis. Skin diseases have a great influence on the mental condition which, in turn, affects the condition of our skin.