This article investigates the association between the use of statins, which are popular in clinical practice and the risk of depressive disorders and suicidal behaviour. It has been observed that low blood cholesterol levels may be associated with the occurrence of depression. However, the findings regarding the impact of statins as lipid profile modifying drugs remain inconclusive. Some studies and meta-analyses indicate that statin use has a protective effect, while others suggest an increased risk of depression or no effect. The studies included in this review do not confirm a significant effect of statin use on suicidal behaviour and the effect of statin use on depression cannot be conclusively established based on these studies. These considerations are based on the possibility that the use of statin drugs may affect central nervous system cholesterol metabolism and serotonergic function. The membrane cholesterol has a significant effect on the serotonergic receptors and the serotonin transporter. The authors emphasise the possibility of a synergistic effect between statins and antidepressants, such as selective serotonin reuptake inhibitors, which could potentially result in enhancements in the patient’s mental state. However, it is imperative to bear in mind the potential for adverse effects when combining these drug groups. Thus recommending heightened patient monitoring. The authors acknowledge the need for further clinical trials to further understand the issue under study.